William married Amanda Jane Jennie Wallace on 15 Jan 1822 in Knoxville, Knox, Tennessee, United States. Amanda (daughter of John Wallace, Sr and Jane Miller) was born on 14 Dec 1804 in Clinton, Anderson, Tennessee, United States; died on 24 Jan 1869 in Hendricks, Indiana, United States. [Group Sheet] [Family Chart]

1. Elizabeth Ann Alexander was born on 28 Apr 1822; and died.
2. Sarah Jane Alexander was born on 7 Sep 1823; and died.
3. Charlotte Alexander was born on 7 Oct 1825; and died.
4. Nancy Alexander was born on 11 Nov 1827; and died.
5. John W. Alexander was born on 13 Mar 1830; died on 26 Nov 1912 in Hendricks, Indiana, United States.
6. Fanny Alexander was born on 12 Mar 1832; and died.
7. Hugh Houston Alexander was born on 23 Mar 1834; and died.
8. Ann Alexander was born on 2 Jul 1836; and died.
9. Francis M. Alexander was born on 7 Apr 1838 in Iredell, Brunswick, North Carolina, United States; died in 1909 in Hendricks, Indiana, United States.
10. Enoch Wallace Alexander was born on 8 Mar 1840.
11. Thomas Benton Alexander was born on 7 Feb 1842 in Iredell, Brunswick, North Carolina, United States; died in 1917 in Hendricks, Indiana, United States.
12. James Knox Polk Alexander was born on 28 Jan 1845; and died.
13. Joseph Alexander was born on 10 Apr 1847; and died.